Tumors of the colon and rectum
ORCHESTRA (Principal Investigator: prof. dr. H.M.W. Verheul)
A randomized multicenter clinical trial for patients with multi-ORgan, Colorectal cancer metastases comparing the combination of cHEmotherapy and maximal tumor debulking versuS chemoTheRapy Alone: ORCHESTRA.
CAIRO 4 (Principal Investigator: prof. dr. H.M.W. Verheul)
The role of surgery of the primary tumour with few or -absent symptoms in patients with synchronous unresectable metastases of colon cancer,a randomized phase III study.
COLONUT (Principal Investigator: Dr. M.A.E van Bokhorst- de van der Schueren and Prof. dr. H.M.W. Verheul)
The effect of individualized nutritional counselling on muscle mass and treatment outcome in patients with metastatic colorectal cancer undergoing chemotherapy.
IMPACT CRC (Principal Investigator: prof. dr. H.M.W. Verheul)
Image guided treatment optimalization with cetuximab for patients with metastatic colorectal cancer: IMPACT - CRC.
Corsica (Principal Investigator: prof. dr. H.M.W. Verheul)
A fase I study of SGI-110 Combined with irinotecan followed by a Randomized phase II study of SGI-110 combined with irinotecan versus regorafenib in previously treated metastatic colorectal cancer patients.
METRIC study (Co-Investigator: prof. dr. H.M.W. Verheul)
MEchanisms of TRaining In patients with Cancer (METRIC) study.
CAIRO 5 (Principal Investigator: prof. dr. H.M.W. Verheul)
Treatment strategies in colorectal cancer patients with initially unresectable liver-only metastases: CAIRO5, a randomised phase 3 study of the Dutch Colorectal Cancer Group (DCCG).
GemDoc (Principal Investigator: prof. dr. H.M.W. Verheul)
A multi-institutional open label, trial evaluating the efficacy of Gemcitabine and Docetaxel in patients with relapsed or refractory metastatic colorectal adenocarcinoma with methylated CHFR and/or microsatellite instability phenotype.
TESAR trial (Principal Investigator: dr. J. Tuynman)
Rectal preserving treatment for early rectal cancer. A multicentred randomized trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer.
PremAb-DOSE TRIAL (Principal Investigator: dr. M. van Egmond and dr. J. van der Vliet)
Pre-operative Administration of Anti-EFGR Monoclonal Antibodies (Cetuximab) for the Eradication of Circulating Tumor Cells in Patients Undergoing Curative Resection of Colorectal Liver Metastases; a dose finding study.
CAIRO 6 (Principal Investigator: dr. J. Tuynman)
Peri-operative systemic therapy and surgery versus surgery alone for resectable colorectal peritoneal metastases: the multicentre, phase II-III, randomised CAIRO 6 study.