Sunrise (Principal investigator: prof. dr. H.M.W. Verheul)
A phase I study of high-dose, intermittent sunitinib in patients with solid tumors.

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VEGF vaccination (Principal investigator: prof. dr. H.M.W. Verheul / dr. J.J. van der Vliet)
A phase I open-label clinical trial, evaluating the therapeutic vaccine hVEGF26-104/RFASE in patients with advanced solid tumors.

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NAPOLY (Principal Investigator: dr. C.W. Menke-van der Houven van Oordt)
A Phase I Open-Label, Safety, Pharmacokinetic and Preliminary Efficacy Study of CriPecĀ® docetaxel in Patients with Solid Tumours.

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MACIST (Principal Investigator: dr. M. van Linde)
Phase Ib study of Metformin and Chloroquine in IDH1/2-mutated Solid Tumors (MACIST).

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MedImmune MEDI0562 (Principal Investigator: dr. J. Voortman)
A Phase 1 Multicenter, Open-label Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Antitumor Activity of MEDI0562 in Combination with Immune Therapeutic Agents in Adult Subjects with Advanced Solid Tumors.

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D6014C00005 FE (Principal Investigator: dr. M. Labots)
A Randomised, Open-label, Phase I Study to Determine the Effect of Food on the Pharmacokinetics of AZD1775 After Oral Dosing of a Capsule Formulation in Patients with Advanced Solid Tumours.

D6014C00007 CA (Principal Investigator: dr. M. Labots)
An Open-Label, Non-randomised, Multicentre study to allow continued access to AZD1775 for patients enrolled in AZD1775 Clinical Pharmacology studies protocols.

BAY 94-9343_18329 (Principal Investigator: prof. dr. H.M.W. Verheul / dr. M. Labots)
An open-label, Phase I study to assess the effect of itraconazole (CYP3A4 and P-gp inhibitor) on the pharmacokinetics of anetumab ravtansine and to assess the ECG effects, safety and immunogenicity of anetumab ravtansine given as a single agent and together with itraconazole in subjects with mesothelin-expressing advanced solid cancers.

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